Grape seed extract is indicated for reducing the risk of atherosclerosis as well as for reducing complications related to diabetes, lowering cholesterol, preventing cancer, and wound healing. Bagchi et al. reported superior antioxidant effect of grape seed extract containing proanthocyanidins compared to other known antioxidants, including vitamin C, vitamin E, and β-carotene. A human clinical trial using hypercholesterolemic subjects showed that grape seed extract supplementation significantly reduced oxidized LDL. Bagchi et al. concluded that grape seed extract may serve as a potential therapeutic tool in promoting cardiovascular health. Electron spin resonance spectroscopy data also showed that grape seed extract containing proanthocyanidins strongly scavenged hydroxyl and superoxide radicals. Grape seed extract is a relatively safe and effective supplement.
There is evidence that grape seed extract is beneficial for a number of cardiovascular conditions. Grape seed extract may help with a type of poor circulation (chronic venous insufficiency) and high cholesterol. Grape seed extract also reduces swelling caused by injury and helps with eye disease related to diabetes.
Many people are interested in grape seed extract because it contains antioxidants. These are substances that protect cells from damage and may help prevent many diseases. However, it’s still too early to say whether the antioxidant properties of grape seed extract really benefit people. Researchers are studying grape seed extract to see if it might lower the risks of some cancers. For now, the evidence is not clear.
Grape seed extract has been studied for use in many other conditions — ranging from PMS to skin damage to wound healing — but the results have been inconclusive
How much grape seed extract should you take?
There is no firmly established dose of grape seed extract. Doses of between 100-300 milligrams/day have been used in studies and are prescribed in some European countries. No one knows what the highest safe dose is.
Can you get grape seed extract naturally from foods?
Grape seed extract comes from grapes. There are no other food sources.
What are the risks of taking grape seed extract?
Side effects. Grape seed extract is generally considered safe. Side effects may include headache, itchy scalp, dizziness, and nausea.
Risks. People allergic to grapes should not use grape seed extract. If you have a bleeding disorder or high blood pressure, talk to your doctor before you start using grape seed extract.
Interactions. If you take any medicines regularly, talk to your doctor before you start using grape seed extract. It could interact with drugs like blood thinners, NSAID painkillers (like aspirin, Advil, and Aleve), certain heart medicines, cancer treatments, and others.
Given the lack of evidence about its safety, grape seed extract is not recommended for children or for women who are pregnant or breastfeeding.
The numerous human intervention studies that became available over time formed the basis for designing an intervention study that employed innovative bio-molecular techniques and reflects conceptual advances in nutritional science. This novel approach enabled to capture the pleiotropic effects of Grape seed extract on vascular health in humans. This physiological benefit can be briefly worded as “maintenance of vascular homeostasis”.